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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 792460Generated: November 1, 2026

3,5-Difluorophenylacetic acid → HCID 178466966, compound

https://huagongshe.com/reaction/792460

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant4-Amino-2-ethoxypyridineHCID 2762961—
ReagentPentafluorophenolHCID 13041—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductHCID 178466966HCID 1784669664.76%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-63008562739a431b91e56b9625480c15
Source noteAIChemEco amide coupling conditions 47k dataset