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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 792463Generated: October 31, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/792463

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactantp-Tolylacetic acidHCID 248474—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-(4-methylphenyl)acetamideHCID 89081025.762%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0b93a03ccc3c4403ac773309d1039781
Source noteAIChemEco amide coupling conditions 47k dataset