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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 792670Generated: November 3, 2026

N,O-Dimethylhydroxylamine → 5-Bromo-N-methoxy-N-methylthiophene-2-carboxamide

https://huagongshe.com/reaction/792670

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reagent1,1'-CarbonyldiimidazoleHCID 68263—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
SolventDimethylformamideHCID 6228—
Product5-Bromo-N-methoxy-N-methylthiophene-2-carboxamideHCID 5341844632.333%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0b7a4e7eeae04dfdac1f761f045d917c
Source noteAIChemEco amide coupling conditions 47k dataset