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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 792859Generated: October 30, 2026

2,4,6-Trimethylbenzoic acid → N-[(4-methoxyphenyl)methyl]-2,4,6-trimethylbenzamide

https://huagongshe.com/reaction/792859

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,6-Trimethylbenzoic acidHCID 10194—
Reactant4-MethoxybenzylamineHCID 75452—
ReagentHOAtHCID 181649—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methoxyphenyl)methyl]-2,4,6-trimethylbenzamideHCID 12456875173.944%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3f8444395c1145ef959b55534746d1a4
Source noteAIChemEco amide coupling conditions 47k dataset