HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium sulfate decahydrate → (6-Methoxypyridin-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium sulfate decahydrate | HCID 62649 | — |
| Reactant | Methyl 6-methoxypyridine-2-carboxylate | HCID 16218333 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (6-Methoxypyridin-2-yl)methanol | HCID 12325389 | 86.9% |
Reaction Steps
To methyl 6-methoxypicolinate (4.65 g, 27.8 mmol) in Et2O (100 mL) was added LAH (1.06 g). The reaction mixture was stirred for 4 hours. Celite (10 g) was added, followed by sodium sulfate-decahydrate (5 g). The reaction mixture was filtered and concentrated to provide the desired product (3.36 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841455B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b27c41fc331140c3b665b704143aa163 |
| Source note | uspto-grants-2014_09 |