HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 2-(Bromomethyl)-6-methoxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (6-Methoxypyridin-2-yl)methanol | HCID 12325389 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Bromomethyl)-6-methoxypyridine | HCID 10081550 | 86.9% |
Reaction Steps
To (6-methoxypyridin-2-yl)methanol (3.36 g, 24.1 mmol) in DCM (30 mL) was added perbromomethane (12.0 g, 36.2 mmol) and triphenylphosphine (9.50 g, 36.2 mmol). The reaction mixture was stirred for 1 hour, concentrated and silica gel chromatography (EtOAc/Hexane 1:5) to provide the desired product (4.23 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841455B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-329eca199b4c468c9768351cf32f991a |
| Source note | uspto-grants-2014_09 |