Ammonium Chloride → HCID 67259271, compound

Participants

Reaction Conditions

Reaction Steps

To 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-4-nitro-1H-indazole (1.13 g, 2.31 mmol) in EtOH/H2O (20 mL/5 mL) was added iron (1.29 g, 23.1 mmol) and NH4Cl (0.124 g, 2.31 mmol). The reaction mixture was heated to 80° C. and stirred for 3 hours. The reaction mixture was concentrated, diluted with EtOAc (30 mL) and Et3N (5 mL). The reaction mixture was heated to reflux for 30 minutes and filtered through Celite®, and the filter pad was washed with DCM/MeOH (50 mL, 10:1). The filtrate was concentrated to provide the desired product (0.89 g).

Provenance & Evidence