Dichloromethane → Dichloromethane methanol ammonium hydroxide

참여 물질

역할	이름	HCID	투입량
반응물	Dichloromethane	HCID 6344	—
반응물	Trifluoroacetic acid	HCID 6422	—
반응물	N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide	HCID 67259695	—
반응물	(3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate	HCID 70814963	—
생성물	Dichloromethane methanol ammonium hydroxide	HCID 21896990	—
생성물	N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide	HCID 67259695	—

반응 단계

Preparation of N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide]: To (3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate (7 mg, 0.01 mmol) in DCM (2 mL) was added TFA (1 mL). The reaction mixture was stirred for 30 minutes, concentrated and silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) gave the final product (3 mg). MS (ES+APCI) m/z=487 (M+H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08841455B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-278158b939ea421c9214b502ed029f5d
출처 메모	uspto-grants-2014_09