HRID79332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID6422

未命名化合物

结构：CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CN(C(=O)OC(C)(C)C)C[C@@H]5O)ccn34)c12

HCID67259560

未命名化合物

PRODUCTS

生成物

HCID21896990

未命名化合物

结构：CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CNC[C@@H]5O)ccn34)c12

HCID67260210

未命名化合物

PROCEDURE

实验过程

To (3S,4S)-tert-butyl 3-(3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridin-7-yloxy)-4-hydroxypyrrolidine-1-carboxylate (22 mg, 0.036 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction mixture was stirred for one hour, and then concentrated under reduced pressure. Silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the desired product (10 mg). MS (ES+APCI) m/z=512 (M+H).

WORKUP

后处理

concentrationconcentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b9e2cf3317534b21baf781694008f75d
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08841455B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][C:22]([O:24][C@@H:25]4[C@@H:29]([OH:30])[CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26]4)=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[C:41]([CH3:45])[N:40]=2)[N:4]=1)[CH3:2].C(O)(C(F)(F)F)=[O:47].[CH2:53]([Cl:55])[Cl:54]>>[CH2:53]([Cl:55])[Cl:54].[CH3:13][OH:14].[NH4+:4].[OH-:47].[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][C:22]([O:24][C@@H:25]4[C@@H:29]([OH:30])[CH2:28][NH:27][CH2:26]4)=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[C:41]([CH3:45])[N:40]=2)[N:4]=1)[CH3:2]