m-Chloroperbenzoic acid → 4-(2-(3(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridin-7-yloxy)ethyl)-1-methylpiperazine 1-oxide

Participants

Reaction Conditions

Reaction Steps

To N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide (25 mg, 0.045 mmol; prepared according to Example 45) in DCM (3 mL) at 0° C. was added metachloroperbenzoic acid (7.8 mg, 0.032 mmol). The reaction mixture was stirred at 0° C. for one hour. The reaction mixture was concentrated under reduced pressure and silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the final product (10 mg). MS (ES+APCI) m/z=569 (M+H).

Provenance & Evidence