4-carboxy-2-isobutyl-6-phenyl-2H-pyridazin-3-one → 4-hydroxymethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one

HRID 7934Notes

Reaction equation

HRID 7934 reaction equation
FC1C=C(C2C(C)=C(O)C(=O)N(CC(C)C)N=2)C=CC=1C.[C:22]([C:25]1[C:26](=[O:41])[N:27]([CH2:37][CH:38]([CH3:40])[CH3:39])[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:30]=1)(O)=[O:23]>>[OH:23][CH2:22][C:25]1[C:26](=[O:41])[N:27]([CH2:37][CH:38]([CH3:39])[CH3:40])[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 219916084-carboxy-2-isobutyl-6-phenyl-2H-pyridazin-3-oneHCID 178419042HCID 178419042, compound

Product 1

HCID 219916284-hydroxymethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-oneYield 22.3%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-isobutyl-6-phenyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 22.3%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-85d77cad6d7d4fc6a9967b37a5758965
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…