6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one → 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one

HRID 7935Notes

Reaction equation

HRID 7935 reaction equation
F[C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=2)[CH:5]=[CH:6][C:7]=1C.OCC1C(=O)N(CC(C)C)N=C(C2C=CC=CC=2)C=1>>[CH2:15]([N:13]1[C:12](=[O:19])[C:11]([CH2:20][O:21][S:22]([CH3:25])(=[O:23])=[O:24])=[CH:10][C:9]([C:4]2[CH:3]=[CH:2][CH:7]=[CH:6][CH:5]=2)=[N:14]1)[CH:16]([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 219915316-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 219916284-hydroxymethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one

Product 1

HCID 219915622-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-oneYield 68.4%

Procedure

Following the procedure of Example 1 (9), 4-hydroxymethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 68.4%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-ac14e02261ea4cb49fe34891bbbfb985
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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