HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2-isobutyl-4-methanesulfonyloxy-6-phenyl-2H-pyridazin-3-one | HCID 21991554 | — |
| Reactant | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 67214099 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one | HCID 67213386 | 83.5% |
Reaction Steps
Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxy-6-phenyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted in N,N-dimethylformamide as a solvent to yield the title compound as a yellow oil (yield: 83.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087606B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-3644b3e033524ed4a71bf1b7ba9b6fa0 |
| Source note | uspto-grants-2006_08 |