Triethylamine → 1-((1,5-dimethyl-1H-pyrazol-3-yl)methyl)-4-nitro-3-vinyl-1H-indazole

Participants

Reaction Conditions

Reaction Steps

To 1-((1,5-dimethyl-1H-pyrazol-3-yl)methyl)-3-iodo-4-nitro-1H-indazole (8.35 g, 21.0 mmol) in THF/IPA (10 mL/30 mL) was added trifluorovinylpotassium borate (5.63 g, 42.0 mmol), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.858 g, 1.05 mmol) and triethylamine (8.79 mL, 63.1 mmol). The reaction mixture was heated to 80° C. for 16 hours. The mixture was diluted with EtOAc (100 mL), washed with H2O and brine, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (Hexane/EtOAc 5:1) to provide the product (5.12 g).

Provenance & Evidence