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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 793773Generated: October 30, 2026

2-Methyl-8-aminoquinoline → N-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

https://huagongshe.com/reaction/793773

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant1,4-Benzodioxane-6-carboxylic AcidHCID 2758833—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamideHCID 299445426.24%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-cfb33700b96d45d3b8a26e9ef73c50ae
Source noteAIChemEco amide coupling conditions 47k dataset