反应详情

温度

87 °C

To a suspension of imidazo[1,2-a]pyridine-3-carboxylic acid (47.6 mg, 0.294 mmol) in NMP (4 mL) was added 2,4,6-trichlorobenzoyl chloride (45.9 μL, 0.294 mmol) and triethylamine (40.9 μL, 0.294 mmol). The reaction mixture was stirred for 30 minutes. 3-Ethyl-1-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-amine (50 mg, 0.196 mmol) was added and the mixture was heated at 87° C. for three hours. The mixture was cooled to ambient temperature and diluted with 10% NaOH aqueous solution (5 mL) and EtOAc (20 mL). The organic phase was washed with water and brine and concentrated under reduced pressure. The residue was triturated with Et2O to give the final product (52 mg). MS (ES+APCI) m/z=400 (M+H).

1. temperatureThe mixture was cooled to ambient temperature
2. washThe organic phase was washed with water and brine
3. concentrationconcentrated under reduced pressure
4. customThe residue was triturated with Et2O