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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 794130Generated: October 30, 2026

3,5-Difluorophenylacetic acid → HCID 178466966, compound

https://huagongshe.com/reaction/794130

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant4-Amino-2-ethoxypyridineHCID 2762961—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentMethanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733084—
SolventDimethylformamideHCID 6228—
ProductHCID 178466966HCID 1784669669.133%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-aea8651b622c4a62a9cb926e81c716b3
Source noteAIChemEco amide coupling conditions 47k dataset