反应详情

A 50 mL round bottom flask was charged with solid potassium tert-butoxide (1.7 g, 14.8 mmol), 2-(4-isopropylpiperazin-1-yl)ethanol (2.88 g, 16.7 mmol), and tert-butanol (10 mL, 103 mmol). The mixture was stirred at ambient temperature for 1 hour before heating at 90° C. for 15 minutes to give a homogeneous mixture. 7-Fluoro-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (1.0 g, 2.3 mmol) was added in one portion. The mixture was heated at 90° C. with stirring for 16 hours. The mixture was cooled to ambient temperature before pouring into a 250 mL round bottom flask containing 150 mL of water. Vigorous stirring at ambient temperature for 2 hours resulted in a beige precipitate. The precipitate was collected by filtration and dried under high vacuum to give the product. MS (APCI), positive scan, m/z=581.1 (M+).

1. temperaturebefore heating at 90° C. for 15 minutes
2. customto give a homogeneous mixture
3. temperatureThe mixture was heated at 90° C.
4. stirringwith stirring for 16 hours
5. temperatureThe mixture was cooled to ambient temperature
6. additionbefore pouring into a 250 mL round bottom flask
7. stirringVigorous stirring at ambient temperature for 2 hours
8. customresulted in a beige precipitate
9. filtrationThe precipitate was collected by filtration
10. customdried under high vacuum
11. customto give the product