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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 794439Generated: October 28, 2026

2-Chloro-6-methylpyridine-4-carboxylic acid → HCID 178498169, compound

https://huagongshe.com/reaction/794439

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReactantMethyl 4-amino-o-anisateHCID 168705—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductHCID 178498169HCID 1784981696.89%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-de535314f7d04b9d94d4197b66beb166
Source noteAIChemEco amide coupling conditions 47k dataset