(3R)-3-fluoropyrrolidine hydrochloride → (R)-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(3-fluoropyrrolidin-1-yl)ethyl)imidazo[1,2-a]pyridine-3-carboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(3R)-3-fluoropyrrolidine hydrochloride	HCID 2759162	—
Edukt	N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-oxoethyl)imidazo[1,2-a]pyridine-3-carboxamide	HCID 86672219	—
Produkt	(R)-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(3-fluoropyrrolidin-1-yl)ethyl)imidazo[1,2-a]pyridine-3-carboxamide	HCID 67260620	—

Reaktionsschritte

Prepared according to procedure for Example 128 from N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-oxoethyl)imidazo[1,2-a]pyridine-3-carboxamide (Example 127, Steps A-B) and (R)-3-fluoropyrrolidin hydrochloride. MS (ES+APCI) m/z=526 (M+H) detected.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08841455B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-c245431e00d34f38b4879b952335b682
Quellennotiz	uspto-grants-2014_09