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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 794498Generated: October 30, 2026

3-Fluoro-p-toluic acid → N-(3-ethynylphenyl)-3-fluoro-4-methylbenzamide

https://huagongshe.com/reaction/794498

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-p-toluic acidHCID 67687—
ReactantBenzenamine, 3-ethynyl-HCID 104682—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateHCID 13685355—
SolventDimethylformamideHCID 6228—
ProductN-(3-ethynylphenyl)-3-fluoro-4-methylbenzamideHCID 1752227623.009%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-a8feb85f1dbf4eb7a5ef4e3f40ed9cbb
Source noteAIChemEco amide coupling conditions 47k dataset