Hydrazine → HCID 67259880, compound

HRID 79455Notes

Reaction equation

HRID 79455 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[N:4]([CH2:14][C:15]([O:17]CC)=O)[N:3]=1.[NH2:20][NH2:21]>CCO>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[N:4]([CH2:14][C:15]([NH:20][NH2:21])=[O:17])[N:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 67261176ethyl 2-(3-bromo-4-nitro-1H-indazol-1-yl)acetate

Product 1

HCID 67259880HCID 67259880, compoundYield 61.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 2-(3-bromo-4-nitro-1H-indazol-1-yl)acetate (1.48 g, 4.51 mmol) in absolute EtOH (20 mL) was treated at ambient temperature with hydrazine (1.45 g, 45.1 mmol) and was heated at reflux for 16 hours under a nitrogen atmosphere. The reaction mixture was cooled to ambient temperature, and the precipitate was isolated by filtration. The solids were dried under vacuum to afford the product (0.865 g) as a tan powder.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours under a nitrogen atmosphere
  3. customthe precipitate was isolated by filtration
  4. customThe solids were dried under vacuum

Sources & evidence

ORD record
ord-bf8e3b566e07458aba1ab44cd33fab30
Source dataset
uspto-grants-2014_09
Patent number
US08841455B2

Reaction notes

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