Acetic Anhydride → N-acetyl-2-(3-bromo-4-nitro-1H-indazol-1-yl)acetohydrazide

HRID 79456Notes

Reaction equation

HRID 79456 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[N:4]([CH2:14][C:15]([NH:17][NH2:18])=[O:16])[N:3]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>C1(C)C=CC=CC=1>[C:19]([N:17]([C:15](=[O:16])[CH2:14][N:4]1[C:5]2[C:10](=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][CH:6]=2)[C:2]([Br:1])=[N:3]1)[NH2:18])(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67259880HCID 67259880, compound

Product 1

HCID 70814862N-acetyl-2-(3-bromo-4-nitro-1H-indazol-1-yl)acetohydrazide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 2-(3-bromo-4-nitro-1H-indazol-1-yl)acetohydrazide (0.865 g) in anhydrous toluene (20 mL) was treated at ambient temperature with 1 equivalent of acetic anhydride. The reaction mixture was stirred at ambient temperature for 16 hours and concentrated under reduced pressure to afford the product (0.98 g) as an off-white solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5b593553204646a98f22630dfcd0595c
Source dataset
uspto-grants-2014_09
Patent number
US08841455B2

Reaction notes

Loading…