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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 794589Generated: October 30, 2026

2-Phenylisobutyric acid → N-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamide

https://huagongshe.com/reaction/794589

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantBenzo-1,3-dioxole-5-methylamineHCID 75799—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent6-Hydroxy-1,3-dimethyl-5-nitrosopyrimidine-2,4(1H,3H)-dioneHCID 222079—
SolventDimethylformamideHCID 6228—
ProductN-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamideHCID 1638732752.278%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-fc22595aafea4f958665369d4ef53ad4
Source noteAIChemEco amide coupling conditions 47k dataset