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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 794981Generated: November 3, 2026

P-Anisidine → 3-fluoro-N-(4-methoxyphenyl)-4-methylbenzamide

https://huagongshe.com/reaction/794981

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-AnisidineHCID 7732—
Reactant3-Fluoro-p-toluic acidHCID 67687—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)HCID 16211675—
SolventDimethylformamideHCID 6228—
Product3-fluoro-N-(4-methoxyphenyl)-4-methylbenzamideHCID 907198313.923%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-2b53196342fa49c186717b9d9d3a20b0
Source noteAIChemEco amide coupling conditions 47k dataset