tert-Butyl piperazine-1-carboxylate → HCID 67213081, compound

HRID 7950Notes

Reaction equation

HRID 7950 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:34]([N:38]1[C:43](=[O:44])[C:42](COS(C)(=O)=O)=[CH:41][C:40]([C:51]2[CH:56]=[CH:55][C:54]([C:57]([F:60])([F:59])[F:58])=[CH:53][CH:52]=2)=[N:39]1)[CH:35]([CH3:37])[CH3:36].N1(C(OC(C)(C)C)=O)CCNC[CH2:62]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:42]2[C:43](=[O:44])[N:38]([CH2:34][CH:35]([CH3:36])[CH3:37])[N:39]=[C:40]([C:51]3[CH:56]=[CH:55][C:54]([C:57]([F:60])([F:58])[F:59])=[CH:53][CH:52]=3)[C:41]=2[CH3:62])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 219915502-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromet hylphenyl)-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 67213081HCID 67213081, compoundYield 83.5%

Procedure

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 83.5%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c1f46b23e6e743a4b919e7d1516313c3
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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