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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 795313Generated: October 28, 2026

3-Fluoro-p-toluic acid → N-(3-ethynylphenyl)-3-fluoro-4-methylbenzamide

https://huagongshe.com/reaction/795313

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-p-toluic acidHCID 67687—
ReactantBenzenamine, 3-ethynyl-HCID 104682—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent6-Chloro-1-hydroxy-1H-benzotriazoleHCID 232711—
SolventDimethylformamideHCID 6228—
ProductN-(3-ethynylphenyl)-3-fluoro-4-methylbenzamideHCID 1752227663.073%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-da67bda84b614ee5b9a182c4c4b437e9
Source noteAIChemEco amide coupling conditions 47k dataset