反应详情

tert-Butyl 4-(5-(3-methoxyphenyl)-1H-pyrrolo[2,3-b]pyri din-4-yl)piperazine-1-carboxylate (0.111 g, 0.272 mmol) was placed in DCM (3 mL) at room temperature. TFA (0.3 mL) was then added, and the reaction was stirred at room temperature for 2 hours. The reaction was then concentrated to dryness, dissolved in minimal DCM, and added dropwise to a stirring solution of 1M HCl in ether. The solid product was filtered, washed with ether, and dried to give 5-(3-methoxyphenyl)-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyri dine (0.083 g, 99% yield) as the dihydrochloride salt.

1. concentrationThe reaction was then concentrated to dryness
2. dissolutiondissolved in minimal DCM
3. additionadded dropwise to a stirring solution of 1M HCl in ether
4. filtrationThe solid product was filtered
5. washwashed with ether
6. customdried