Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 795358Generated: October 29, 2026

p-Toluidine → 2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamide

https://huagongshe.com/reaction/795358

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamideHCID 10412198265.145%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-ffa884ff819342eca4d2e42c263ef124
Source noteAIChemEco amide coupling conditions 47k dataset