反应详情

(R)-tert-Butyl 4-(4-chlorophenyl)-5-(4-(5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazin-1-yl)-2-methyl-5-oxopentan-2-ylcarbamate (0.026 g, 0.042 mmol) was placed in DCM (3 mL) at room temperature. TFA (0.3 mL) was then added, and the reaction was stirred at room temperature for 1 hour. The reaction was then concentrated to dryness. The resulting residue was dissolved in minimal DCM and added to a stirring solution of 1M HCl in ether. The resulting solid product was collected by filtration, washed with ether, and dried to give (R)-4-amino-2-(4-chlorophenyl)-1-(4-(5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazin-1-yl)-4-methylpentan-1-one (0.019 g, 76% yield) as the dihydrochloride salt. MS ESI (+) m/z 521 detected.

1. concentrationThe reaction was then concentrated to dryness
2. dissolutionThe resulting residue was dissolved in minimal DCM
3. additionadded to a stirring solution of 1M HCl in ether
4. filtrationThe resulting solid product was collected by filtration
5. washwashed with ether
6. customdried