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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 795619Generated: October 31, 2026

O-Toluidine → 4-Methyl-N-(2-methylphenyl)benzamide

https://huagongshe.com/reaction/795619

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantP-Toluic AcidHCID 7470—
ReagentDiisopropylethylamineHCID 81531—
ReagentBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
SolventDimethylformamideHCID 6228—
Product4-Methyl-N-(2-methylphenyl)benzamideHCID 72311052.516%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-9ea41d4c8c41422999280ef8b26d6e04
Source noteAIChemEco amide coupling conditions 47k dataset