反应详情

tert-Butyl 4-(5-phenyl-1H-pyrrolo[2,3-b]pyri din-4-yl)piperazine-1-carboxylate (0.40 g, 1.06 mmol) was placed in DCM (10 mL). TFA (2 mL) was then added, and the reaction was stirred for 1 hour. The reaction was concentrated to dryness, redissolved in minimal DCM, and added to a stirring solution of 1M HCl in ether. The resulting solid was collected by filtration, washed with ether, and dried to give 5-phenyl-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine dihydrochloride (0.350 g, 94.3% yield).

1. concentrationThe reaction was concentrated to dryness
2. dissolutionredissolved in minimal DCM
3. additionadded to a stirring solution of 1M HCl in ether
4. filtrationThe resulting solid was collected by filtration
5. washwashed with ether
6. customdried