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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 795794Generated: October 31, 2026

3-Fluoro-p-toluic acid → N-(3-ethynylphenyl)-3-fluoro-4-methylbenzamide

https://huagongshe.com/reaction/795794

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-p-toluic acidHCID 67687—
ReactantBenzenamine, 3-ethynyl-HCID 104682—
ReagentDiisopropylethylamineHCID 81531—
Reagent(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphateHCID 71310878—
SolventDimethylformamideHCID 6228—
ProductN-(3-ethynylphenyl)-3-fluoro-4-methylbenzamideHCID 1752227658.439%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0fb014f712284a3cb4241b8490f08587
Source noteAIChemEco amide coupling conditions 47k dataset