6-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one → 6-(3,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 7961Notes

Reaction equation

HRID 7961 reaction equation
F[C:2]1C=CC(C2C(C)=C(O)C(=O)N(CC(C)C)N=2)=[CH:4][C:3]=1[CH3:21].[F:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:31]=[C:32]([C:37]([O:39][CH3:40])=[O:38])[C:33](=[O:36])[NH:34][N:35]=2)[CH:26]=[CH:27][C:28]=1[F:29]>>[F:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:31]=[C:32]([C:37]([O:39][CH3:40])=[O:38])[C:33](=[O:36])[N:34]([CH2:2][CH:3]([CH3:21])[CH3:4])[N:35]=2)[CH:26]=[CH:27][C:28]=1[F:29]

Participants

3

Reactant 2

HCID 219915566-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 178419053HCID 178419053, compound

Product 1

HCID 219916596-(3,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (6), 6-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: quantitative).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-af73b051fe144fdba335731eb1906f61
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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