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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 7963Generated: October 25, 2026

6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one → 6-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/7963

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 9842449—
Reactant4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 21991638—
Product6-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-oneHCID 2199145325%

Reaction Steps

Following the procedure of Example 1 (8), 4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 25.0%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07087606B2
Source datasetuspto-grants-2006_08
ORD IDord-fdde27bcafa44772a696d31f27493e13
Source noteuspto-grants-2006_08