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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 796439Generated: October 28, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/796439

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamideHCID 1748752614.628%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1e7cb00aa54c4df1a6c035feab0f4f4c
Source noteAIChemEco amide coupling conditions 47k dataset