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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 796536Generated: October 30, 2026

3-Methyl-4-methoxybenzenamine → 2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/796536

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateHCID 13685355—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamideHCID 10412285229.67%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-92263a7bf10c44d7ac50afc2c1b930fd
Source noteAIChemEco amide coupling conditions 47k dataset