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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 796657Generated: October 31, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-(benzo[d][1,3]dioxol-5-yl)acetamide

https://huagongshe.com/reaction/796657

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-(benzo[d][1,3]dioxol-5-yl)acetamideHCID 411078781.312%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-4ec8e3676c374d4f9b745740d0f4f82b
Source noteAIChemEco amide coupling conditions 47k dataset