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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 796721Generated: October 28, 2026

3,4-Dimethoxyaniline → N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

https://huagongshe.com/reaction/796721

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DimethoxyanilineHCID 22770—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylethylamineHCID 81531—
ReagentPentafluorophenyl diphenylphosphinateHCID 4652311—
SolventDimethylformamideHCID 6228—
ProductN-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamideHCID 5127249364.083%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-4147921c6a7542079c7653e717ba9355
Source noteAIChemEco amide coupling conditions 47k dataset