6-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one → 6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 7969Notes

Reaction equation

HRID 7969 reaction equation
FC1[CH:3]=[C:4]([C:9]2C=C(CO)C(=O)N(CC(C)C)N=2)[CH:5]=CC=1F.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[C:30]1[CH:31]=[C:32]([C:37]([O:39][CH3:40])=[O:38])[C:33](=[O:36])[NH:34][N:35]=1>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[C:30]1[CH:31]=[C:32]([C:37]([O:39][CH3:40])=[O:38])[C:33](=[O:36])[N:34]([CH2:3][CH:4]([CH3:9])[CH3:5])[N:35]=1

Participants

3

Reactant 2

HCID 219914536-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-oneHCID 219916986-(2,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219914116-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-oneYield 84.8%

Procedure

Following the procedure of Example 1 (6), 6-(2,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 84.8%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-da69e8aadcb04131b7b10677babb8669
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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