6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one → 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 7970Notes

Reaction equation

HRID 7970 reaction equation
FC1C=C(C2C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=2)C=CC=1F.[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[C:34]1[CH:35]=[C:36]([C:45]([O:47]C)=[O:46])[C:37](=[O:44])[N:38]([CH2:40][CH:41]([CH3:43])[CH3:42])[N:39]=1>>[C:45]([C:36]1[C:37](=[O:44])[N:38]([CH2:40][CH:41]([CH3:42])[CH3:43])[N:39]=[C:34]([C:28]2[CH:29]=[CH:30][C:31]([F:33])=[CH:32][C:27]=2[F:26])[CH:35]=1)([OH:47])=[O:46]

Participants

3

Reactant 2

HCID 219914116-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 219915206-(3,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one

Product 1

HCID 219916134-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (7), 6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 92.7%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-db2f469dbd3242369371d21ba7dc441a
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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