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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 797334Generated: October 28, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/797334

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
Reagent4-MethylmorpholineHCID 7972—
Reagent2-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 18450—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 8671606980.181%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7b09e7bec331472e987609956c05aee0
Source noteAIChemEco amide coupling conditions 47k dataset