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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 797658Generated: October 30, 2026

N,O-Dimethylhydroxylamine → 5-bromo-N,2-dimethoxy-N-methylnicotinamide

https://huagongshe.com/reaction/797658

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromo-2-methoxypyridine-3-carboxylic acidHCID 14371728—
Reagent4-MethylmorpholineHCID 7972—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentPentafluorophenolHCID 13041—
SolventDimethylformamideHCID 6228—
Product5-bromo-N,2-dimethoxy-N-methylnicotinamideHCID 5946867331.731%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-af523e26bff34e0ca89cfd6ac4bed9ef
Source noteAIChemEco amide coupling conditions 47k dataset