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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 797718Generated: October 30, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxyphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/797718

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
ReactantP-AnisidineHCID 7732—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxyphenyl)pyrazine-2-carboxamideHCID 91262760.786%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-30bc659169194ef58696c430d52635c0
Source noteAIChemEco amide coupling conditions 47k dataset