tert-Butyl piperazine-1-carboxylate → 2-benzyl-4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7979Notes

Reaction equation

HRID 7979 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:34]([N:41]1[C:46](=[O:47])[C:45]([CH2:48]OS(C)(=O)=O)=[CH:44][C:43]([C:54]2[CH:59]=[CH:58][C:57]([F:60])=[C:56]([CH3:61])[CH:55]=2)=[N:42]1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.N1(C(OC(C)(C)C)=O)CCNCC1>>[CH2:34]([N:41]1[C:46](=[O:47])[C:45]([CH2:48][N:11]2[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:13][CH2:12]2)=[CH:44][C:43]([C:54]2[CH:59]=[CH:58][C:57]([F:60])=[C:56]([CH3:61])[CH:55]=2)=[N:42]1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 21991515HCID 21991515, compoundHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219917022-benzyl-4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 91.8%

Procedure

Following the procedure of Example 1 (10), 2-benzyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 91.8%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4ff9cb33be7e4153becfd1f708da72b0
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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