Dimethylamine → 2-benzyl-4-dimethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7981Notes

Reaction equation

HRID 7981 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([CH2:15]OS(C)(=O)=O)=[CH:11][C:10]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH3:28])[CH:22]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][NH:30][CH3:31]>>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([CH2:15][N:30]([CH3:31])[CH3:29])=[CH:11][C:10]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH3:28])[CH:22]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 21991515HCID 21991515, compound

Product 1

HCID 219916022-benzyl-4-dimethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 92.7%

Procedure

Following the procedure of Example 7, 2-benzyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 92.7%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ab159311283c473e80d4c3406696396e
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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