L-Proline → HCID 66620681, compound

Participants

Role	Name	HCID	Charge
Reactant	L-Proline	HCID 145742	—
Reactant	HCID 57263372	HCID 57263372	—
Reactant	(1-{2-[5-(9,9-Difluoro-7-{2-[2-(2-methoxycarbonylamino-3-methyl-butyryl)-2-aza-bicyclo[2.2.1]hept-3-yl]-3H-benzoimidazol-5-yl]-9H-fluoren-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester	HCID 66620162	—
Product	HCID 66620681	HCID 66620681	—

Reaction Steps

was prepared in a similar fashion to (1-{2-[5-(9,9-Difluoro-7-{2-[2-(2-methoxycarbonylamino-3-methyl-butyryl)-2-aza-bicyclo[2.2.1]hept-3-yl]-3H-benzoimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Example DK), replacing the proline derivative with the corresponding 4-cyano-proline derivative.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08841278B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-46c43def2d9549eba28703e11f2657f7
Source note	uspto-grants-2014_09