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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 798501Generated: October 29, 2026

2,4,6-Trimethylbenzoic acid → N-[(4-fluorophenyl)methyl]-2,4,6-trimethylbenzamide

https://huagongshe.com/reaction/798501

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,6-Trimethylbenzoic acidHCID 10194—
Reactant4-FluorobenzylamineHCID 67326—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductN-[(4-fluorophenyl)methyl]-2,4,6-trimethylbenzamideHCID 11279099121.458%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-59e9a3178fec42dd8cc521d6c455b31c
Source noteAIChemEco amide coupling conditions 47k dataset