Dimethylamine → 2-cinnamyl-4-dimethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7986Notes

Reaction equation

HRID 7986 reaction equation
[CH2:1]([N:10]1[C:15](=[O:16])[C:14]([CH2:17]OS(C)(=O)=O)=[CH:13][C:12]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[C:25]([CH3:30])[CH:24]=2)=[N:11]1)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:31][NH:32][CH3:33]>>[CH2:1]([N:10]1[C:15](=[O:16])[C:14]([CH2:17][N:32]([CH3:33])[CH3:31])=[CH:13][C:12]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[C:25]([CH3:30])[CH:24]=2)=[N:11]1)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 738582982-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxy methyl-2H-pyridazin-3-one

Product 1

HCID 672132642-cinnamyl-4-dimethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 90.9%

Procedure

Following the procedure of Example 7, 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 90.9%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9099d3a220c64814acf549559f07b0ba
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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