6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 4-carboxy-2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7987Notes

Reaction equation

HRID 7987 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[Cl:26][C:27]1[CH:54]=[CH:53][C:30]([CH:31]=[CH:32][CH2:33][N:34]2[C:39](=[O:40])[C:38]([C:41]([O:43]C)=[O:42])=[CH:37][C:36]([C:45]3[CH:50]=[CH:49][C:48]([F:51])=[C:47]([CH3:52])[CH:46]=3)=[N:35]2)=[CH:29][CH:28]=1>>[C:41]([C:38]1[C:39](=[O:40])[N:34]([CH2:33][CH:32]=[CH:31][C:30]2[CH:53]=[CH:54][C:27]([Cl:26])=[CH:28][CH:29]=2)[N:35]=[C:36]([C:45]2[CH:50]=[CH:49][C:48]([F:51])=[C:47]([CH3:52])[CH:46]=2)[CH:37]=1)([OH:43])=[O:42]

Participants

3

Reactant 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 672135792-(4-chloro-cinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 672131804-carboxy-2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 86.2%

Procedure

Following the procedure of Example 1 (7), 2-(4-chloro-cinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow crystalline powder (yield: 86.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-24c70d4868564ed4aaa651e7184c89a3
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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